Epigenetic mechanisms regulate genome accessibility and cell differentiation. This course investigates epigenetic phenomena: heritable alternate states of gene activity that do not result from alteration in nucleotide composition (mutations). In addition, there will be two exams including answering short questions and an assay critiquing an original paper that is selected on a topic in Cell Biology. Accordingly, class participation/discussion is essential and the grade will be determined significantly by that. There is no assigned text students learn to critically evaluate current literature by reading original papers on selected topics in modern cell biology. Intensive classroom discussions focus on the experimental methods used, results obtained, interpretation of these results in the context of cell structure and function, and implications for further studies. Rather, the primary objective of this course is to teach those students considering a career in the biomedical sciences how to read, discuss, and question research papers effectively. CAMB/BIOL 480 does not attempt to cover all aspects of cell biology, and is therefore not appropriate for students seeking a lecture course that provides a comprehensive survey of the field. This course is designed for beginning graduate students and advanced undergraduate students with a particular enthusiasm for Cell Biology. Prerequisites: College level biochemistry and cell biology CAMB 4800 (BIOL 4800): Advanced Cell Biology Topics will include genome sequencing, analysis of sequences and microarrays, and new techniques including high-throughput sequencing and reverse genetic analysis with a focus on genome-wide mutant collections. This course will be a focused study of genomes, genomic techniques, and how these approaches are and will be used in diagnosing and treating human disease. Prerequisites: BIOL 2210 BIOL 4210 strongly recommended. IDEAL (Inclusion, Diversity, Equity, and Learner) Research.New Student Email & UPHS Network Username.New Student Financial Information (2023).
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